ACE2 PET in healthy and diseased conditions

Angiotensin converting enzyme 2 (ACE2) played a critical role in regulating renin-angiotensin-aldosterone system (RAAS). In this research, 68Ga-cyc-DX600 was synthesized as PET tracer of ACE2 imaging. positron emission tomography/magnetic resonance (PET/MR) preliminary administered on twelve healthy volunteers, and the images were normalized registered to establish standard model PET. diseased conditions, 18F-FDG compared for COVID-19 (one acute phase three post-COVID), anemia (n = 1) malignancies 2) evaluate diagnostic efficiency. definite dependence. For uptake PET/MR female male, differences existed salivary glands, upper respiratory tract kidneys, meanwhile, age, body mass index (BMI) also confounding factors. RAAS-related tissue organs relatively higher uptake, such SUVmean cardiac chamber (3.786 ± 1.495), liver (5.342 2.267), spleen (4.465 2.508), kidney (4.906 1.619 8.431 5.179 male). COVID-19, revealed fluctuations, particularly susceptible organs, including liver, testis. case anemia, activated local RAS bone marrow diffuse high uptake. added supplementary information FDG 68Ga-cyc-DX600-based models established visually monitoring whole-body expression. The feasibility supervising disease primarily proved providing comprehensive view process functional recovery.